Nicotine Cell Proliferation And Invasion - 1807 Words

Journal Assignment 2 Background Purpose of the research The purpose of this research is to show that nicotine induces cell proliferation and invasion as well as epithelial to mesenchymal transition (EMT), even though nicotine is not carcinogenic on its own. These series of inductions of mechanisms lead to lung cancer as well as breast cancer and pancreatic cancer. Type of cells chosen for study The lung cancer cells especially in non-small cell lung cancer (NSCLC) are the primary target cells for this study. In addition to the lung cancer cells, the human breast cancer cells and pancreatic cancer cells are selected for the study in order to compare and confirm the similar activities of the gene expression and mechanism that induce these cancers. Background of the topic Nicotine is the primary component of tobacco products, which causes addiction and can eventually lead to lung cancer through series of metabolic activities. (http://www.carcinogenesis.com/article.asp?issn=1477-3163;year=2013;volume=12;issue=1;spage=1;epage=1;aulast=Warren ) Nicotine, which results from cigarette smoking, is found to be the major cause of lung cancer. Non-small cell lung cancer (NSCLC) is referred to as a type of lung cancer that is associated with epithelial cells (http://www.cancer.gov/cancertopics/pdq/treatment/non-small-cell-lung/healthprofessional/page1 ). The lung is covered by layers of epithelial cells connected with junctions that provide the function of transporting and secretingShow MoreRelatedCancer Results From Abnormal, Unregulated Cell Growth2141 Words   |  9 PagesBACKGROUND Cancer results from abnormal, unregulated cell growth which can create physiological impairments in body tissues (1). Two adverse characteristics of cancer cells include the ability to invade other tissues and the inability to die (2). Cells generally become cancerous due to changes in gene expression and subsequent errors in protein function (2). These faults in genes and physiology can be caused by mutations which can result from exposure to carcinogens. One of the most common substancesRead MoreLong Term Management Plan After 45min Consultation1987 Words   |  8 PagesWe would like to consider this patient as a whole instead of 2 different illnesses. This patient is chronically depressed and recently being diagnosed with stage 3a Non Small Cell Lung Cancer. It is very difficult to formulate long term management plan after 45min consultation because information available about patient expectations and concerns are limited. In order to arrange patient centered management , patie nt participation is very important, because patient had stopped antidepressant and counsellingRead MoreCase Studies67624 Words   |  271 Pagesrequirement (and a concern that many foreign producers do not face). While technology has been a driver of change, labour agreements and relations have not always made it possible to fully exploit the benefits of technological improvements. The proliferation of substitute materials is an important issue. It is important to note, however, that while substitutes have made significant inroads into steel markets over the last 30 years, they will likely Case 9 Nucor Corporation and the US steel industry